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Oxymetholone (also known as anapolon or anadrol) is a very drastic synthetic steroid, 17-alpha-alkylated modification of dihydrotestosterone. It was developed for the treatment of osteoporosis and anaemia, as well as to stimulate muscle gain in malnourished and debilitated patients. Oxymetholone has been approved by the American Food and Drug Administration (FDA) for use in humans. Later there where created non-steroidal drugs that effectively could treat anaemia and osteoporosis; because of this anapolon lost his popularity and by 1993 Syntex decided to cease the production of the drug, as well as other manufacturers did. By its performance parameters oxymetholone is most similar to methandienone. As with methandienone, it provokes not only active muscle bulking, but also a significant increase in power performance. However, a large part of the gained weight is because of water retention in the body, which can lead to high blood pressure on cycle. Thanks to its ability to influence the level of hemoglobin and to increase the blood volume in the body, oxymetholone may cause an extremely strong pumping effect by athletes, which consequently complicates the training process, because muscles get sore almost immediately after the first heavy set. Oxymetholone is a derivative of dihydrotestosterone, which gives it a chemical structure that does not aromatize. Despite the fact that oxymetholone does not directly convert to estradiol, it itself has pronounced estrogenic properties. It should be remembered that because of this peculiarity only antiestrogens would be able to combat with estrogenic side effects, but not aromatase inhibitors, because aromatase is not involved into the process. Some suggest that oxymetholone`s estrogenic activity relates to the progestogenic one, like with nandrolones. Side effects may be similar. However, medical studies have shown that oxymetholone does not possess any progestogenic activity.



Buy Oxymetholone 50mg, sold under the brand names Anadrol and Anapolon among others, is an androgen and anabolic steroid (AAS) medication which is used primarily in the treatment of anemia.[3][4] It is also used to treat osteoporosisHIV/AIDS wasting syndrome, and to promote weight gain and muscle growth in certain situations.[3] It is taken by mouth.

Medical uses.

The primary clinical applications of Buy Oxymetholone 50mg include treatment of anemia and osteoporosis, as well as stimulating muscle growth in malnourished or underdeveloped patients.[3] However, in the United States, the only remaining FDA-approved indication is the treatment of anemia.

Non-medical uses.

Oxymetholone is used for physique- and performance-enhancing purposes by competitive athletesbodybuilders, and powerlifters.

Side effects

The common side effects of oxymetholone include depressionlethargyheadacheswelling, rapid weight gainpriapism, changes in skin color, urination problems, nauseavomitingstomach pain (if taken on an empty stomach), loss of appetitejaundicebreast swelling in men, feeling restless or excited, insomnia, and diarrhea.[12] In women, side effects also include acne, changes in menstrual periodsvoice deepeninghair growth on the chin or chestpattern hair lossenlarged clitoris, and changes in libido.[3][12] Because of its 17α-alkylated structure, oxymetholone is hepatotoxic.[3] Long term use of the drug can cause a variety of serious ailments, including hepatitisliver cancer, and cirrhosis; therefore periodic liver function tests are recommended for those taking oxymetholone.[13]



Androgenic vs. anabolic activity
of androgens/anabolic steroids hide

Medication Ratioa
Testosterone ~1:1
Androstanolone (DHT) ~1:1
Methyltestosterone ~1:1
Methandriol ~1:1
Fluoxymesterone 1:1–1:15
Metandienone 1:1–1:8
Drostanolone 1:3–1:4
Metenolone 1:2–1:30
Oxymetholone 1:2–1:9
Oxandrolone 1:3–1:13
Stanozolol 1:1–1:30
Nandrolone 1:3–1:16
Ethylestrenol 1:2–1:19
Norethandrolone 1:1–1:20
Notes: In rodents. Footnotes: a = Ratio of androgenic to anabolic activity. Sources: See template.

Like other AAS, oxymetholone is an agonist of the androgen receptor (AR).[3] It is not a substrate for 5α-reductase (as it is already 5α-reduced) and is a poor substrate for 3α-hydroxysteroid dehydrogenase (3α-HSD), and therefore shows a high ratio of anabolic to androgenic activity.[3]

As a DHT derivative, oxymetholone is not a substrate for aromatase and hence cannot be aromatized into estrogenic metabolites.[3] However, uniquely among DHT derivatives, oxymetholone is nonetheless associated with relatively high estrogenicity, and is known to have the potential to produce estrogenic side effects such as gynecomastia (rarely) and water retention.[3][14][15][16] It has been suggested that this may be due to direct binding to and activation of the estrogen receptor by oxymetholone.[3] Oxymetholone does not possess any significant progestogenic activity.

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